Plant Transcription Factor Database
Previous version: v3.0
Solanum lycopersicum
ZF-HD Family
Species TF ID Description
Solyc01g014970.1.1ZF-HD family protein
Solyc01g102980.2.1ZF-HD family protein
Solyc01g103810.1.1ZF-HD family protein
Solyc01g103820.1.1ZF-HD family protein
Solyc01g103830.1.1ZF-HD family protein
Solyc01g103840.1.1ZF-HD family protein
Solyc02g067310.2.1ZF-HD family protein
Solyc02g067320.1.1ZF-HD family protein
Solyc02g067330.1.1ZF-HD family protein
Solyc02g085160.1.1ZF-HD family protein
Solyc02g087970.1.1ZF-HD family protein
Solyc03g061620.1.1ZF-HD family protein
Solyc03g098060.1.1ZF-HD family protein
Solyc03g116070.1.1ZF-HD family protein
Solyc04g014260.1.1ZF-HD family protein
Solyc04g074990.2.1ZF-HD family protein
Solyc04g080490.2.1ZF-HD family protein
Solyc05g007580.1.1ZF-HD family protein
Solyc05g018740.1.1ZF-HD family protein
Solyc05g020000.1.1ZF-HD family protein
Solyc05g051420.1.1ZF-HD family protein
Solyc09g089550.2.1ZF-HD family protein
ZF-HD Family Introduction

This group of sequences described by a 54-residue domain found in the N-terminal region of plant proteins, the vast majority of which contain a ZF-HD class homeobox domain toward the C terminus. The region between the two domains typically is rich in low complexity sequence. The companion ZF-HD homeobox domain is described in INTERPRO:IPR006455.

A one-hybrid screen resulted in the cloning of four different members of a novel class of plant homeodomain proteins, which are most likely involved in the mesophyll-specific expression of the C4 PEPCase gene in C4 species of the genus Flaveria. Inspection of the homeodomains of the four proteins reveals that they share many common features with homeodomains described so far, but there are also significant differences. Interestingly, this class of homeodomain proteins occurs also in Arabidopsis thaliana and other C3 plants. One-hybrid experiments as well as in vitro DNA binding studies confirmed that these novel homeodomain proteins specifically interact with the proximal region of the C4 PEPCase (C4 phosphoenolpyruvate carboxylase) gene. The N-terminal domains of the homeodomain proteins contain highly conserved sequence motifs. Two-hybrid experiments show that these motifs are sufficient to confer homo- or heterodimer formation between the proteins. Mutagenesis of conserved cysteine residues within the dimerization domain indicates that these residues are essential for dimer formation. Therefore, we designate this novel class of homeobox proteins ZF-HD, for zinc finger homeodomain protein. Our data suggest that the ZF-HD class of homeodomain proteins may be involved in the establishment of the characteristic expression pattern of the C4 PEPCase gene.

Windhovel A, Hein I, Dabrowa R, Stockhaus J.
Characterization of a novel class of plant homeodomain proteins that bind to the C4 phosphoenolpyruvate carboxylase gene of Flaveria trinervia.
Plant Mol Biol. 2001 Jan;45(2):201-14.
PMID: 11289511